Fig. 1 Schematic representation of reversible modifications of histone H3K4, K9, and K27.
Posttranslational modifications of histone tails are crucial epigenetic marks that regulate diverse cellular processes.
DNA methylation and covalent modifications of histone tails contribute to changes in chromatin architectures, either enhancing or repressing gene expression.
Dear Editor, The methylation modifications of histone 3 lysine 4 (have) havessentialal effects on biological processes including gene expression and transcription, cell cycle progression, and DNA repair.
We showed that modifications of histone H3-Lys9 at gene promoters correlated well with mRNA expression in human bone marrow MSCs.
Post-translational modifications of histone proteins such as acetylation and methylation are crucial for heterochromatin formation and thus play a key role in remodeling the oocyte genome.
Many efforts have been focused on the mechanisms by which the post-translational modifications of histone tails regulate the higher-order chromatin architecture.
These observations are matched at the molecular level by epigenetic modifications such as methylation of cytosines in the DNA and methylation, acetylation, and other modifications of histone proteins wrapped around the DNA in chromosomes.
In this study, we demonstrate that chronic exposure to MeHg (10 μM) causes epigenetic landscape modifications of histone H3K4 trimethylation (H3K4me3) marks in Caenorhabditis elegans using chromatin immuno-precipitation sequencing (ChIP-seq).
In hip3-1 mutantseveralral modifications of histone H3 were aberrant at the SPCC663.14c+ promoter.
Several modifications of histone H3 occurred extensively at the SPCC663.14c+ locus in hip3-1 cells.
