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It can be proposed that mitosis-specific modifications of either NFAT5 or the chromatin, or a repressor protein interacting with NFAT5 in mitosis might disrupt the binding of this factor to DNA.
Static cysteine modifications of either carbamidomethylation (IAM-alkylation, +57.0215 Da) or ethanolyl (IE-alkylation, +44.0262 Da) were included on the basis of which modifying reagent was used.
Straightforward modifications of either approach allow us to incorporate the positivity and sum to less than or equal to one constraints of linear mixing.
This revealed additional peaks corresponding to mass differences of 178 and 258 Da, which were respectively identified as gluconoyl and phospho-gluconoyl post-translational modifications of either lysine residues and/or the N-terminal methionine residue (Supplementary Figure S3).
Abratt et al (1997) used GC in stage IIIB/IV patients delivering cisplatin on day 15 resulted in good response rate (52%), median survival (13 months) associated with low haematological toxicity and very few dose modifications of either gemcitabine or cisplatin.
In addition, our preliminary results, that suggest co-expression with MuSK and Dok-7 increases further the sensitivity of the test, leaves open the possibility that intracellular modifications of either AChR or MuSK (which both have intracellular as well as extracellular domains), or changes in the packing geometry of the clusters, can influence binding of these low affinity antibodies.
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This framework allows speedy modification of either local or global requirements and is highly portable to other complex planning problems.
Three collapses that occurred at initial 800 m length of southern tunnel necessitated modification of either or both of the support system or excavation sequences.
Using an in vitro pull-down assay, we demonstrate that the interaction between transport inhibitor response 1 (TIR1) and Aux/IAA proteins does not require stable modification of either protein.
In conclusion, mPEG-modification of either RSV or the host cell is a highly effective prophylactic strategy for preventing viral infection.
Since heteromeric assembly of both subunits is required for efficient functional expression, post-transcriptional modification of either subunit would affect NMDA receptor activity.
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