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To avoid such adverse side effects, studies have looked at both modifications of drug action and alternative methods of drug delivery.
The major approaches used are chemical modifications of drug molecules and/or new drug delivery systems, which offer better targeting to the upper skin layer, faster onset, and lower concentrations.
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The passage of drugs through the BBB may be improved through biological modifications of drugs involving the coupling of the drug to a receptor-targeted delivery vector such as a genetically engineered peptidomimetic monoclonal antibody[21 24].
The mean follow-up period was 89 days (62 115 days), and during the follow-up there were no significant modifications of drugs among patients.
Various strategies can influence drug design in the decision-making process in the structural modification of drug candidates to reduce metabolic instability.
The present paper deals with the modification of drug release from an HPMC‐based matrix tablet of a sparingly water‐soluble drug, prednisolone (PDL), using (SBE 7M‐β‐CD as a solubilizing agent.
Modification of drug delivery nanomaterials with affinity molecules that facilitate targeting, has rendered a new class of ligands for cell receptors, which often possess valency and dimensions different from natural counterparts.
This finding further supports the results obtained previously regarding colloid stabilization efficacy (Kasza, 2017) that amphiphilic hyperbranched polyglycerol is an ideal alternative to Pluronics in the functional surface modification of drug carrier NPs.
From these findings, particle-shape modification of drug crystals and dry particle coating with nanoparticle agglomerate using a mechanical powder processor is expected as an innovative technique for preparing controlled-release coated particles having high drug content and size smaller than 100 μm.
This has demonstrated effectiveness particularly in the modification of drug use.
However six patients developed drug induced hepatitis which all of them recovered with modification of drug therapy.
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