Sentence examples for modifications of critical from inspiring English sources

If gamma zein contains intramolecular disulfide bonds, modifications of critical cysteines in soluble thioredoxin gamma zein fusion protein might prevent disulfide bond formation and result in misfolded and insoluble protein in Escherichia coli.

Remethylation pathways are potentially inhibited in vivo by pro-oxidants, due to known redox modifications of critical enzymes [23].

Indeed, they show that modifications of critical nodes in these pathways can affect the kinetics and thermodynamics of the allosteric mechanism.

In response to oxidative stress, the E3 ubiquitin ligase is inactivated through the modification of critical cysteine residues of Keap1, thereby allowing the accumulation of Nrf2 and its translocation into the nucleus (Zhang et al., 2004; Villeneuve et al., 2010).

This unbalance could lead to higher hydrogen peroxide production, which may concur to oxidative stress causing defective insulin gene expression due to modification of critical factors that modulate the insulin promoter.

Section 7(a)(2) of the Endangered Species Act requires Federal agencies to ensure that actions they authorize, fund, or carry out do not jeopardize the continued existence of an endangered species or result in the destruction or adverse modification of critical habitat.

Upon challenges by oxidative or electrophilic stresses that could involve potential modification of critical cysteine residues in Keap1 and or Nrf2 itself coupled with phosphorylation by kinases, Nrf2 is released from Keap-1, translocates into the nucleus, dimerizes with small Maf proteins, binds to ARE and transcriptionally activates Nrf2-ARE target genes [4].

Disruption of the Nrf2-Keap1 canplex can result from modification of critical cysteines of Keap1.

During a large or sustained epidemic, even after modification of critical care standards, available resources will remain taxed.

The primary mechanism by which redox signalling occurs is through the post-translational modification of critical cysteine residues (thiols) in redox-sensitive proteins.

Thus, increasing our knowledge of the mechanisms governing the targeting of storage proteins to the different organelles will ultimately allow the modification of critical steps in this process, leading to improvements of crop plants as a protein source.