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Dynamic regulation of diverse nuclear processes is intimately linked to covalent modifications of chromatin.
Finally, we evaluated if the observed modifications of chromatin condensation affect the transcriptional profile.
Covalent modifications of chromatin have emerged as key determinants of the genome's transcriptional competence [1 3].
However, recent reports reveal novel functions of FKBPs in the nucleus, which include regulation of transcription factors, histone chaperone activity, and modifications of chromatin structure.
Global and local modifications of chromatin structure underlie callus formation, and the combination and sequence of epigenetic modifications further shape intricate cell fate changes.
Notably, modifications of chromatin structure occur primarily during callus formation via an in vitro tissue culture process and, thus, pluripotent callus cells have unique epigenetic signatures.
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These reversible transitions are based on complex epigenetic regulatory mechanisms (e.g. the induction of changes in the modifications of chromatin-associated histones) during epithelial-mesenchymal transitions [ 385, 386].
As a consequence of a complex and not yet understood interplay between chromatin condensation state, transcriptional activity, and modifications of chromatin-organizing proteins, chromatin subsets are termed euchromatin and heterochromatin (4, 5).
Sado, T., Hoki, Y. & Sasaki, H. Tsix silences Xist through modification of chromatin structure.
It is generally believed that structural modification of chromatin governs the transcriptability of the template1, and consequently studies have been carried out on the activity of chromatin2 4.
Polycomb group (PcG) proteins are transcriptional repressors that help to maintain cellular identity during metazoan development by epigenetic modification of chromatin structure.
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