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Varland, S., Osberg, C. & Arnesen, T. N-terminal modifications of cellular proteins: the enzymes involved, their substrate specificities and biological effects.
In conclusion, these results indicate that GGT activity confers a growth advantage unrelated with intracellular glutathione supply, and are consistent with the interpretation that cisplatin resistance is the consequence of modifications of cellular pharmacokinetics as a result of extracellular drug inactivation by thiol metabolites originated by GGT-mediated GSH cleavage.
Small nucleolar RNAs (snoRNAs) guide nucleotide modifications of cellular RNAs in the nucleus.
Therefore, monitoring of adverse effects as well as modifications of cellular and molecular defense systems can both be used as biomarkers [9, 16, 21, 22].
These small RNAs are involved in guiding functional important posttranscriptional modifications of cellular RNAs, mainly rRNAs, and are therefore often abundantly expressed.
In this study, we identified the various oxidative modifications of cellular Nm23-H1 UPLC-ESI-q-TOF-q-tandemndeMSMS including S-glutathionylation of Cys109.
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As well as Atg3 and Atg7 oxidation, we detected reversible thiol modification of cellular Atg4B and Atg10 by H2O2.
The cytotoxic mechanism of many quinones has been correlated to covalent modification of cellular proteins.
Recombinase-mediated AGIS provides a useful tool for the modification of cellular genomes.
Metabolic engineering is the intentional modification of cellular metabolism for the production of desired compounds.
Though reported limitedly in tissue engineering, modification of cellular functions can be achieved by culturing them into multicellular spheroids.
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