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These methods include genetic modifications of cells; for example, replacing MHC genes, expression of Fas ligand, or modifications of other antigenic epitopes.
Although this approach provides many advantages over direct radiolabelling methods, it requires gene modifications of cells and therefore is not broadly translated into the clinic.
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Furthermore, modifications of cell surface may contribute to stiffness increase.
Until now, two main proposes are epigenetic and genetic modifications of cell fate.
By means of Fluorescence microscopy we analysed the modifications of cell and nucleus architecture induced by the different substrata.
Recently, modifications of cell surface properties and master regulators have been shown to be effective approaches for enhancing stress tolerance.
Our question was: might modifications of cell shape reflect on nuclear morphology and architecture and hence on chromatin function, in order to represent a mechanism of cell regulation?
Upon PrPc down regulation in cultured enterocytes, we observed modifications of cell morphology and an arrest of cell growth.
These modifications of cell behavior are particularly intriguing since high rates of proliferation and migration represent two fundamental characteristics of malignant cells.
Altered expression of pPLAIIIδ affects plant growth and size through modifications of cell expansion and elongation.
The protein may mediate BR-induced growth via modifications of cell wall properties and metabolism.
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