Sentence examples for modifications of biomolecules from inspiring English sources
On the whole, the modifications of biomolecules that are mediated by HOX are numerous and highly damaging, which makes these oxidants highly effective toxic defense molecules that can be exploited by the human immune system to fight off microbial infection.
Reactive oxygen and nitrogen species (ROS and RNS, respectively), which are generated as a byproduct of many biochemical processes or as a result of environmental oxidative stress, cause specific and both reversible (signaling) and irreversible (oxidative damage) oxidative modifications of biomolecules, including proteins, lipids and DNA.
Indeed, oxidative stress associated modifications of biomolecules are known hallmarks of the aging brain [ 11, 72] and it is expected that heavy ion radiation with its propensity to cause higher oxidative stress and increased damage to biomolecules could accelerate changes in brain commonly associated with aging.
In the same way, the analysis of subtle modifications of biomolecule content in the blood vessels (BVs) could reveal tumour growth in different stages [ 14].
Bioconjugation, defined as chemical modification of biomolecules, is widely employed in biological and biophysical studies.
Inhaled environmental stressors damage the airways and lung parenchyma, producing irritation, recruitment of inflammatory cells, and oxidative modification of biomolecules.
The modification of biomolecules with mPEGs is denoted PEGylation, and mPEGs are usually activated for selective PEGylation of amino groups of biomolecules under mild conditions [1, 3, 6, 7].
In summary, HYNIC represents a well-established way to exploit the highly reactive hydrazine group, to generate bioconjugate chemistry with a degree of bioorthogonality offering the possibility for highly efficient and site specific modification of biomolecules for imaging.
Living in an aerobic environment brings along constant oxidative modification of biomolecules as part of normal tissue turn over.
Inspection of the greatly different chemical structures and polarities of both compound classes shows that modification of biomolecules by HNE or oxidized phospholipids may elicit quite different effects.
The GO analysis indicated that the overrepresented functional categories were most likely related to cell response, modification of biomolecules, and the immune function (Additional file 1: Table S7).
