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We have used mass spectrometry to analyze modifications of all core histones in Arabidopsis.
The selected adducts represent modifications of all four nucleobases at various reactive sites and with differing polarity.
Next-generation proteomic technologies are poised to provide deep information on tumor proteomes and on post-translational modifications of all types.
We strongly encourage some modifications of all reporting guidelines to include items on sensitivity analyses as a way to enhance their use and reporting.
In the research reported here, we tested and optimized the performance of the approach by analyzing a mixture of 18 DNA adducts including modifications of all four nucleobases at various reactive sites producing adducts with differing polarities.
In spite of major advances in proteomic [ 1, 2] and cytometric [ 3– 7] methods, quantification of the levels and post-translational modifications of all proteins of the proteome in the same cell is still beyond reach.
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To determine if such alterations are a general property of the repressor, we assessed the extent of coordination of modifications on all individual blocks of affected chromatin.
This methodology is applicable to the modification of all plasmids that replicate in E. coli and is not restricted by plasmid size.
The Federal Aviation Administration has ordered a modification of all Boeing 747 jets in an effort to avert accidents like the one that killed 520 people aboard a Japan Air Lines flight last year.
Re-engineering the prototype vector AAV2 using epitope insertion, chemical modification, and molecular evolution not only demonstrated the flexibility of the best-studied serotype, but now also expanded the tool kit for molecular modification of all AAV serotypes.
Significant changes of the JET NB system will be carried out within the next few years and will include modification of all PINIs, modification or replacement of various beamline components and corresponding instrumentation, procurement and installation of new high voltage power supply (HVPS) units and corresponding control systems and refurbishment of the 36 kV power distribution.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com