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To exclude the possibility that the inserted modification might generate a hypomorphic allele, we tested if the tagged form of PC-1 was able to rescue embryonic lethality in Pkd1 knock-out mice.
The modification and redistribution of these proteins might generate antigenic determinants to which no tolerance exists, thereby eliciting a primary immune response.
Large number of retrovirus infections might cause strong epigenetic modifications by the chromosomal integration of retroviruses, and the use of HDAC inhibitor might generate chromosomal instability (Sakurada 2010).
Honesty might generate trust.
These might generate 20percentt of the building's electricity.
Eventually, such collaborations might generate revenue.
That firestorm might generate some unintended consequences, however.
To explain the heritability, through mitosis, of VPA-induced changes in histone modification at Hoxb promoters, we describe how an epigenetic feed-forward loop, based on cross-talk between H3 acetylation and H3K4 methylation, might generate a persistently increased steady-state level of histone acetylation in response to a transient signal.
This modification in the SUMD scale should be taken into account when comparing our results with other studies, since our methods used to extract factor scores might generate different insight constructs.
If CHG methylation is not sufficient for the gene silencing, interaction and/or collaboration with other layers of epigenetic modifications might be important for generating silent heterochromatin.
Once this process evolved, he argued, minor modifications might have been enough to generate the great range of colored patterns observed in nature.
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