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The extra N-terminal sequence of rTFF1/BC was not involved in the trefoil factor functional domain, but glycosylation modification might enhance the interaction of cell surface receptors or mucins with rTFF1, as compared to rTFF1/EC.
Nanofibers have shown good biological performances such as improved cell adhesion and differentiation; therefore, nanofibrous modification of dental and bone implants might enhance osseo-integration.
Also vaccination with modified AML cells, such as AML-derived DC or fusions between AML cells and DC, has been investigated; further modification of DC with 4-1BB-L or CD40 might enhance the efficacy of such vaccines [ 10– 13].
Although the precise mechanisms of these effects have not been clarified, our hypothesis is that FP might enhance arginase activity of RBC through oxidative modifications, resulting in reduced NO synthesis and/or availability.
Further modifications of the recombinant neurofibromin e.g. the fusion of one or more HIV TAT transduction domains might enhance the cellular and cytoplasmic uptake as well.
Well here's another idea that might enhance that effort.
This might enhance acceptability and feasibility.
Nevertheless, it might enhance the filtering performance.
Nevertheless, the fact that both the BRCA1/BARD1 E3 ligase and the BRCC36 deubiquitinating enzyme are present at DNA damage sites raises the possibility that additional ubiquitin modifications might be necessary to enhance or maintain the ubiquitin signaling events initiated by the RNF8/RNF168 ligases.
This and other 5′ and 3′ end modifications might provide alternative approaches to enhancing Cas9:sgRNA assembly and activity in cells.
Modifications might then be offered.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com