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Mr. Samaras, who has worried Greece's lenders with suggestions that terms of the deal could be renegotiated, added that "policy modifications might be required to guarantee the full program's implementation".
Neither Mr. Kerry nor his aides provided any details on what specific projects were envisioned, who might invest and what modifications might be required in Israeli restrictions on the West Bank for the plan to work.
Otherwise, additional cis/ trans-factors or protein modifications might be required to fully facilitate this hetero planta system.
Chemical modifications might be required to improve the stability of the siRNA molecules and minimize the non-specific immunogenicity.
Thus, RNA-dependent DNA methylation acting together with histone modifications might be required to selectively shut down a subset of rRNA genes by forming heterochromatic states that have been shown to be associated with inactive rRNA genes.
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Considering that post translational modification might be required for the E3 ligase activity of OsPUB15, we pre-incubated the purified His-OsPUB15 with the total protein extracts of rice and used such pre-incubated His-OsPUB15 for the in vitro ubiquitination assay.
Remarkably, this study further showed that phosphorylation of MBD4 by PKC may potentiate its activity to process 5-meC, suggesting that posttranslational modification might be required to unleash a potentially harmful but dormant 5-meC glycosylase activity in certain DNA glycosylases for targeted demethylation under specific conditions (Fig. 5a).
It then also covers the differences between different Cortex-M processors, and the software modifications which might be required when porting software between them.
Such a modification step might be required before HAMLET can compete with F-actin for binding to α-actinin.
BLM alone is insufficient to stimulate the activity of PICH in vitro, suggesting that other components of this complex or post-translational modifications or both might be required for this process.
CHO cells allow proper protein folding and post-translational modifications such as human-like glycosylation which might be required for biological efficacy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com