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Rather co-enrichment of these modifications may reflect a physical interaction between the distal elements and the MYC promoter through large chromatin loops.
Therefore, genomic distribution of specific histone modifications may reflect the underlying organization of the genome.
Moreover, 4-HNE can form adducts on DNA bases and modifies mtDNA thus measurement of such modifications may reflect the level of mitochondrial alterations [ 11].
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The hypersensitivity of the R3/R4 fate decision to modification may reflect the complexity of the fate choice (and the feedback loop) compared to the relative simplicity of the decision to rotate clockwise vs. counterclockwise.
Observed modification may reflect differences in case phenotype; for example, non-Hispanic blacks were more likely to have co-occurring ID in our data compared with other racial/ethnic groups.
Modifications that may reflect diverse calcium-versus-magnesium layering aberrations are treated extensively in professional literature.
Alternatively, reduction of global histone modification levels may reflect conversion of chromatin from a euchromatic to a heterochromatic state.
"These lower early post-modification delinquency rates may reflect HAMP's emphasis on the affordability of monthly payments and the requirements to verify income and complete a successful trial period," the report noted.
Initially, we combined data from all three cell types, in order to observe generalized trends of histone modification patterns which may reflect fundamental features of eukaryotic cells.
However, these modifications may not reflect the immediate effect of transcriptional repression and could be a later consequence [ 60].
In addition to acetylation, novel mitochondrial post-translational modifications have emerged that may reflect the metabolic state, including succinylation and malonylation (Du et al, 2011; Peng et al, 2011).
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