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Recent studies suggest that tau, upon alternative mRNA splicing and multiple posttranslational modifications, may participate in the regulations of intracellular signal transduction, development and viability of the neurons.
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In particular, some studies have suggested that some types of histone modifications (HMs) may participate in the alternative splicing and function as exon marks.
Nonetheless, some histone modifications may also participate in chromosome condensation, indicating their importantce in the cell cycle and cell mitosis [ 9, 10].
Taken together, our results indicate that important transcription factors, which serve to function in chromatin modification, together with DNA methylation may participate in regulating common patterns of gene expression in chronic epilepsy.
Each of these protein domains may participate in a particular modification step of the tightly packed triple-helical collagen structure [11], [12].
These TGFβ-induced modifications on expression of TGF receptors and Smads may participate in the chondrocyte-phenotype changes observed in OA, a pathology associated, at least in the first stage, with an increase in the TGFβ level [ 9].
Such modifications of CHIP likely dictate recruitment of cofactors which in turn may participate in restricting the type and length of ubiquitin chains produced [ 45, 46].
We therefore hypothesized that Grx1 may participate in a crosstalk across the mitochondrial membrane through the modification of mitochondrial membrane proteins.
The moderate Democratic Left party may participate as well.
However, other mechanisms may participate.
It is suggested that Cbfa1 may participate in chondrocyte differentiation.
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