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There exist, however, very few general methods by which to relate modifications to expectations of effects, and even fewer that enable understanding of how multiple modifications may interact.
An informative example is North American canids (Canis), where body size, prey availability, and human landscape modifications may interact and impose local selective pressures.
This would imply that these modifications may interact and regulate each other under different conditions, provide read-out for different interacting partners, attribute multiple functions to the same protein and may play an important role in cell signaling cascades (Fig. 5).
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As gene expression could be regulated also by post-translational histone modifications, which, in turn, may interact with the methylation of cytosines, we decided to explore H3K27me3 and H3K4me3, abundant histone marks in Arabidopsis [ 24].
Few studies have considered modification effects from genetic variants that may interact with the type of consumed fluids.
Note that TATA-containing genes may interact with some specific chromatin modification factors to regulate gene expression [ 29].
Though these effect modifications were weak, it seems that sex and socioeconomic status may interact in determining health perception.
Peroxynitrite is a strongly reactive oxidant that may interact with multiple proteins and cause nitrosative modification of tyrosine residues to form nitrotyrosine.
The repetitive structure and glycan modifications associated with many Leishmania cell surface molecules suggest that these parasites may interact with CLRs, for example, MR and DC-SIGN [ 6, 45].
These strategies often involve modifications to the spatial and temporal scheduling of harvest activities, and these strategies may interact in unexpected ways.
In such circumstances, ROS may interact with cellular biomolecules, such as DNA, leading to modification and potentially serious consequences for the cell [ 8].
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