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Obviously, if one forces two dependent ES descriptors to be combined in a single equation, the signs in the regression coefficients of key structural modifications may change, and thus fail to point out the real tendency of impact to ligand binding in an analog set.
First, such modifications may change the result of protein domain search like InterProScan that are handled in different places (e.g. Chado, GBrowse MySQL, GreenPhylDB).
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Surface modification may change the interaction of ENPs with living organisms.
Work modifications may include changes to the workplace, equipment, work design and organisation, working conditions and/or work environment [ 5].
Moreover, post-translational modifications may induce changes in Rad9-binding mode and allow it to interact with other partners (Du et al, 2006; Hammet et al, 2007).
Although some cis-regulatory modifications may occur without changes in protein binding affinities, the genome-wide binding site modifications we document here are likely to have functional consequences.
These modifications may lead to changes in signal transduction, ionic homeostasis, scavenging of reactive oxygen species, accumulation of compatible solutes and growth regulation [ 3, 6, 16– 16].
Our results indicate that there is an age-associated increase in nitrative modification and carbonylation to CKm, that these modifications correlate with significant decreases in activity and that these modifications may induce structural changes that promote oligomerization and aggregation.
Depending on the developmental stage at which the alterations in chromatin structure occur, modifications may lead to neuroanatomical changes in the organism that last throughout its lifespan whereas other transcriptional changes may be temporary and affect behavior within specific circumstances.
Differences in measured levels of protein modifications may be due to changes in both the modification stoichiometry and expression levels of the modified protein.
Although these modifications may result in minor changes in future studies compared with our results, they were made to improve the content of the questionnaire and can be expected to improve the psychometric performances of the EDSQ.
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