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Structural modifications leading to a higher TPSA will ultimately lead to an increased number of H-bond donors and/or acceptors and reduced lipophilicity.
After the source code was leaked in 2000, community coders took on updates and modifications leading to the excellent Falcon 4.0: Allied Force title from Lead Pursuit.
From the above discussion, it appears convincing that the CNS drugs can serve as suitable leads for non-CNS targets after appropriate structural modifications leading to considerable alterations in their property space.
These data suggest that knowledge of the post-translational modifications leading to increased or decreased half-life of the Mcl-1 protein in B cells may lead to important therapeutic applications in CLL, as well as in other forms of cancer.
In fact, the comparison suggested the microstructure modifications leading to representations with non-uniformly distributed fibres.
Synthetic scaffold modifications leading to an increase in molecular complexity were studied.
There are apparently 50 base weapons in the game but over 700 modifications, leading to the creation of guns like the plasma sniper riffle and tactical junk jet.
Deconvolution was then used to assess balance performance and to guide further design modifications leading to the final balance design.
By using an optimization method presented in the companion paper, Part I, the optimal structural modifications leading to minimization of the vibratory response are found.
Physical modifications leading to a homogenization of previously diverse littoral habitats increasingly affect the ecological integrity of lake shores in urban landscapes.
Cytoskeleton modifications leading to altered localization of nuclear factors may result in loss- or gain-of-function of such factors, which affects the cell cycle and cell development.
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