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The use of different matrices together with different surface modifications is often time-consuming and inefficient in practice, plus immobilization by covalent bond reagents may result in deactivation of the enzymes (Ko et al. 2012).
In addition to altered DNA methylation, an array of histone post-translational modifications is often abnormal in human cancer, and proteins responsible for modifying chromatin are similarly altered [10], [11], [12].
Yet, compliance to such lifestyle modifications is often poor, especially in adolescents.
The pattern of these modifications is often thought of as a code and can influence which other proteins get recruited.
However, the synthesis of compounds analogous to their natural equivalents, based on chemical characteristics or with minor structural modifications, is often necessary.
Analysis of protein posttranslational modifications is often complicated by the low stoichiometry of the modifications, which is further complicated by the low abundance of many target proteins.
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"EPA explained that vehicle modifications are often performed to increase engine power or boost fuel economy, but that these modifications increase vehicle emissions and thus violate the Clean Air Act," the Library of Congress said in its final rule.
Housing activists counter that homeowners seeking modifications are often told by their lenders to stop payments, and then end up in foreclosure.
Epigenetic modifications are often retained when cells divide, and can sometimes be passed on to offspring.If inherited epigenetic changes were causing daughter rotifers to produce more catalase, it would raise the question of whether a similar thing happens in other species and, if so, whether it might be induced artificially, without all the tedious business of a lifetime's starvation.
These modifications were often observed concomitantly with nanoparticle aggregates.
Surface modifications are often used to increase the functionality of nanoconjugates.
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