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Modifications in vital cellular molecules can provoke alterations in the cellular structure causing malfunctions that may finally result in apoptosis or necrosis.
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Recent studies have shown that not only single epigenetic modifications but also combinations of multiple epigenetic modifications play vital roles in gene regulation.
Histone modifications play vital roles in transcriptional regulation, for instance, chromosome condensation [ 55], DNA replication, alternative splicing [ 70], and DNA repair [ 71].
It is currently proposed that histone modifications play vital roles in many fundamental biological processes by rearranging the structure and composition of chromatin.
Alternatively, our DIS group may have received more sedation because of the protocol modification requiring sedation resumption because of changes in vital signs.
Protein ubiquitination and SUMOylation are vital post-translational modifications in numerous signaling pathways36,37,38,39.
There is an increasing amount of evidence to show that chromatin modifications play a vital role in pre-mRNA splicing.
Histone modifications play a vital role in determining these states of chromatin during growth and development [4].
Epigenetic modifications play a vital role in tumor development, progression, and metastasis.
Dietary modifications play a vital role in reducing symptoms and improving glycemic control.
The information conveyed by epigenetic modifications plays a vital role in regulating DNA-mediated processes, including transcription, DNA repair, and replication [ 2].
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