Sentence examples for modifications in this histone from inspiring English sources

We found lower levels of H3K9me2 in subjects with occupational exposure to Ni; however, urinary Ni was not clearly associated with modifications in this histone.

Since the modification of histones can only occur in chromosomal regions in which relevant histones are present, it is common practice to view levels of histone modifications in relation to histone levels, as used in this study [ 21].

Despite the evident role of histone modifications in colon cancer, histone modification profiles have not been analyzed in coupled normal and tumor colon samples.

To determine whether KDM5C regulates specific histone modifications in HCC cells, histone modification patterns were measured after modulation of KDM5C expression.

Moreover, this marker has been also related to epigenetic modifications in H3K4 histone [ 36], thereby supporting our hypothesis of this type of modification in our model.

It is not clear whether this heterogeneity reflects OLPs at different stages of their differentiation, or whether different subtypes of OLPs are marked by the difference in this histone modification [17].

We have used this effect in order to investigate the role of histone modifications in this example of nuclear reprogramming.

Also, the model's capability to investigate influence of modifications in one histone type compared to another is being refined.

Aberrant histone modifications in particular histone acetylation, which lead to misregulation in gene expression, are also a characteristic feature of human cancer cells.

The major pathways affected include DNA methylation, different site-specific modifications in histone proteins, and microRNAs.

61, 62 Similarly, epigenetic changes in breast cancer cells (such as modifications in histone acetylation and DNA methylation at specific gene regulatory elements) have been implicated in breast oncogenesis.