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Although good infection control practices are the most important measure in limiting the spread of resistance, other measures are required, including changes in antimicrobial drug prescribing patterns through formulary modification and enhanced education of prescribers (5 ).
It is proposed that these histone modifications counteract the spreading of a compact heterochromatic structure.
This model incorporates current biological understanding of the processes involved in the spreading of histone modifications, such as diffusion and modification induced recruitment of methyl- and acetyltransferases.
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The model proposed earlier could well explain the spread of these modifications.
The presence of other histone modifications, such as histone variant H2A.Z, methylation of lysine residues 4 and 79 of histone H3 and the acetylation of lysine 16 in histone H4, may limit the spread of the Sir complex [ 8- 12].
Fighting the spread of AIDS in Africa.
These modifications occur in proteins that induce cancers, and scientists believe that drugs that block protein prenylation can be a means to prevent the spread of the disease in an individual.
However, there is little molecular evidence for the spreading of 'heterochromatic' chromatin modifications over a repressed variegating gene in vertebrates.
This mechanism could also account for the spreading of marks such as the repressive modifications H3K9me3 and H3K27me3 over large domains in differentiated cells.
Although the timely new chapters are spread throughout all of the book, the vital section on post-translational modifications has been expanded most to reflect the increasing importance of these modifications in the understanding of protein function.
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