Sentence examples for modifications in the regulatory from inspiring English sources

The purpose of this study was to determine whether the proinflammatory effect of GC arise from epigenetic pattern modifications in the regulatory regions of proinflammatory genes.

In recent years there has been an increased focus on the development of novel technologies for the preparation of age-appropriate formulations, supported by modifications in the regulatory framework [11].

That little is known about the modifications occuring in the regulatory pathways during malignant transformation has been due, in part, to the lack of experimental models in which the transformation of normal cells by a relevant oncogene can be finely controlled and followed [17].

The Review Committee viewed the summary document, subsequent media releases, and oral presentations to be inappropriately selective in the use of material from the white papers such that they seemed to suggest that public concerns were without scientific basis and largely resulted from media bias hence requiring no significant modification in the current regulatory and enforcement regimes.

Nevertheless, many proteins, particularly in eukaryotes, are unstructured (natively disordered) or contain large unstructured regions.These regions frequently contain motifs, such as signalling sequences or sites of posttranslational modifications, that are involved in the regulatory functions of a cell [38], [39].

The more pleiotropic developmental genes could rely more heavily on modifications in the protein and cis-regulatory sequences, rather than on gene duplication for diversifying function [ 57].

Therefore, the target-specific changes of histone modifications in transcriptional regulatory elements or latency-related genes could either be mediated directly by low level of viral proteins produced by provirus or occur when the HIV-1 latent cells were established [ 28].

These results are in good agreement with those of recent studies showing that H2A.Z colocalizes with active histone modifications in transcription regulatory regions [ 7, 10, 30- 32].

Through a transcriptome analysis, we detected a different pattern of mRNA transcription in the liver at birth comparing male vs female and microsomic vs normal mice, noting some modifications in epigenetic regulatory genes in females and modifications in some growth factor genes in males.

This model represents a strong explicative tool to describe modifications in regulatory cascades that may account for the evolution of tooth structures [ 1, 24, 25].

Modifications in regulatory sequences allowing unique expression patterns, addition of new domains, and modifying the amino acid sequence of the DCX domains themselves explains – at least in part- why this superfamily is thriving.