Gene Ontology analyses of these genes showed that they are involved in nucleic acid metabolism, protein modification, signalling, and in the cell cycle and/or protein transport.
The microtubule cytoskeleton forms the most prominent structural system in Trypanosoma brucei, undergoing extensive modifications during the cell cycle.
This is particular significant as several recent studies indicate that perturbation of cilia formation or function observed in several genetic diseases results in drastic modification of the cell cycle [38].
Yet during ovarian follicle cell development, at least four genomic intervals are over-replicated in a modification of the cell cycle, increasing the amount of DNA template available for transcription [ 55].
In addition, many replication fork-associated proteins undergo modifications in response to the cell cycle or DNA damage.
An alternative possibility is that Dop is regulated by phosphorylation or other post-translational modification through the cell cycle machinery and that, in the absence of Cdk1-dependent phosphorylation, its phosphorylation state is changed.
Aurora B protein is subject to extensive posttranslational modification throughout the cell cycle.
Nonetheless, some histone modifications may also participate in chromosome condensation, indicating their importantce in the cell cycle and cell mitosis [ 9, 10].
This leads to the possibility that YY1 is regulated by post-translational modification, phosphorylation in particular, to play specific roles at specific time points in the cell cycle.
Starved cells are immobile and arrested in the cell cycle.
