Sentence examples for modifications in protein from inspiring English sources
We have developed an integrated bioinformatics resource, which consolidated and mapped all currently available information on genetic modifications in protein kinase genes with sequence, structure and functional data.
The ModFinder module provides new methods to identify and classify protein modifications in protein 3D structures.
Moreover, in contrast to CMV, modifications in protein metabolism were not affected by PSV duration.
Although alterations/ post translational modifications in protein expression have been extensively quantified, complementary analysis of nuclear membrane proteome changes have been limited.
Accurately identifying modifications in protein sequences is a critical first step for PTM profiling, and thus our approach may benefit routine proteomic analysis.
Interestingly, our previous investigations of time-dependent gene expression changes of three cell lines (A549, BEAS 2B and Met5A) also indicated modifications in protein ubiquitination and ion transport after exposure to crocidolite asbestos fibres [ 5].
Quantitative assessment of post-translational modifications in proteins by mass spectrometry often requires the consideration of the alteration in ionization efficiency of peptides induced by the modification.
MGO is known to induce aggregation and structural modifications in proteins through cross-linking and formation of chemical adducts [7], [8].
Antioxidant redox systems and antioxidant enzymes neutralize ROS, but oxidative stress may induce posttranslational modifications in proteins modulating ROS activities.
This reactivity has been exploited previously in the chemical modification of thiostrepton, the mapping of Ser/Thr modifications in proteins, the design of solid-phase capture resins, and the identification of lanthipeptides.
The exponential increase in genome sequences and the experimental characterization of a large number of amino acid modifications in proteins has created a bottleneck in connecting known PTMs to the genes catalyzing them (4).
