Albeit with some empirical parameters, the proposed NECI method needs no parameter modification in practice, and its adaptability and robustness are proved by extensive tests and some of them are shown in a previous section.
Theoretically, one of the great advantages of CCO designs is that individual data can be included to estimate effect modifications, but in practice most CCO-based studies on the relationship between air pollution and health do not analyze effect modification at the individual level.
Although some feminist philosophers adhered to mainstream philosophical traditions and pursued women's issues within those frameworks, others were convinced that treating gender as a category of philosophical analysis would entail major modifications in the practice of philosophy.
This may be achieved through modifications in current practice and models to involve the factor of return-on-investments, as reported in this work.
These new drugs brought dramatic modifications in psychiatric practice and research as a new study methodology had to be developed for a field that was, until then, virtually absent from pharmacological therapies.
Further studies could assess to what extent modifications in clinical practice and/or external interventions might cause changes in the patient mix.
The variation of parameters from one year to another may reflect modifications in medical practice (medical orientation rather than research focus and content of cancer genetic clinics) and/or scientific breakthroughs in cancer genetics such as identification of genes predisposing to cancer.
