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We are also evaluating the role of epigenetic modifications, in particular DNA methylation, as potential mediators of the health effects of metals.
Although in the recent years much progress has been made in identifying readers of histone modifications, in particular methylation, recognition of the majority of known histone marks is still poorly understood.
In response to cellular requirements, USP25 would undergo several modifications, in particular, monoubiquitination at K99 or sumoylation at the same residue (Figure 6A).
The reviewers therefore find that with some modifications, in particular to the discussion, this paper should be suitable for eLife.
Epigenetic modifications, in particular age-related CGI methylation, have been suggested to contribute to the field defect in the colon (Issa et al, 1994; Shen et al, 2005).
Aberrant histone modifications in particular histone acetylation, which lead to misregulation in gene expression, are also a characteristic feature of human cancer cells.
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We also discuss the biological consequences of cholesterol modification, in particular the use of cholesterol as a molecular handle in the spatial deployment of the protein signal in developing tissues.
One is based on the material pore structure modification, in particular on the presence of big enough interconnected pores and channels.
In the next section, the reduction of these bubble parameters is shown to be a result of the surface modification, in particular the increased surface wettability, found for the nanofluid-boiled surfaces.
RNAi guides histone modification, in particular methylation of H3 at lysine 9 (H3K9me2) which is characteristic for heterochromatin, via an interaction between complexes containing small interfering RNAs (siRNAs) and nascent transcripts at the locus [12].
Ling and hake may also be unequally affected by ecosystem fluctuations or modification, in particular, the benthic foraging of ling makes it potentially vulnerable to any negative impacts of bottom trawling on benthic fauna.
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