Methylation is a widely occurring chemical modification in nucleic acids and proteins.
Protein arginine methylation is a post-translational modification commonly found in nucleic acid-binding proteins [reviewed in [ 1, 2].
Exposure to X-rays can lead to specific modifications in proteins and nucleic acids, including bond rupture.[ 9] In both UOX:5-PMUA and UOX:5-PIU crystals, we observed that the C5=Op1 bond is susceptible to selective radiolysis at low X-ray doses (Movie S3).
Gene Ontology analyses of these genes showed that they are involved in nucleic acid metabolism, protein modification, signalling, and in the cell cycle and/or protein transport.
114 These results demonstrate a key role for FTO in nucleic acid repair or modification; however, it is still far from clear what the connection between this mechanism and obesity actually is.
IPA analyses revealed that the proteins with functions in RNA post transcriptional modifications, and nucleic acid metabolism are prominent among proteins with decreased ubiquitination, illustrated in Figures 5a and 5b, respectively.
We found that these genes were involved in nucleic acid metabolism (126 genes), post-translational modifications (72 genes), protein folding (26 genes), and cell death and survival (525 genes).
When ONOO- acts as an oxidant, it produces nitrite and a hydroxide ion rather than isomerising to nitrate and can react with proteins (tyrosine nitration or direct reactions with specific amino acids), lipids (lipid peroxidation) and nucleic acids (oxidative modifications in nucleobases).
Chemical modifications of nucleic acids, often driven by the needs of antisense research, target in part the five-membered cycle or its analogues in order to tailor their conformation towards the desired needs [1, 2].
