Mass spectroscopy analysis identified citrulline-modifications in multiple proteins in inflamed CIA joint and EAE brain tissue.
The established resource not only provides an important reference for molecular biologists to understand and explain the regulatory mechanisms of miRNA and epigenetic modification in multiple types of biological processes but also offers potential epigenetic-associated biomarkers for predicting, diagnosing and treating diseases.
Lysine acetylation is a reversible posttranslational modification involved in multiple cellular processes, where an acetyl group is transferred to the epsilon-amino group of an internal lysine residue of a protein.
Nitrosylation is believed to be an important post-translational modification involved in multiple human diseases [ 87, 105], and may prove to be the mechanism by which peroxynitrite induces muscle atrophy.
To our knowledge, this is the first time that the community of intensivists has been provided with translational research exploring a major aspect of epigenetics (here, histone modifications) in sepsis-related multiple organ dysfunction syndrome (MODS).
Among the substrates for palmitoylation are Vac8, SNAREs, and Ras2, indicating important regulatory functions for this FA modification of proteins in multiple pathways involved in membrane trafficking and signaling.
Further, the modulations of histone methylation and acetylation by chrysin might initiate several levels of chromatin modification in the multiple sites such as −684 to −692, −2549 to −2557 required for transcriptional regulation of p21 gene [ 51].
Multiple modifications in the hydrogen bonding pattern to P resulted in systematic changes of the free energy gap.
Of note, many of the programs reviewed have been subject to modifications over time, resulting in multiple iterations or versions.
In the cases demonstrated in Figures 4 and 5, peptide-level measurements would have great difficulty to simultaneously quantify correlated changes in multiple modifications in a proteotypic (gene-specific) fashion.
Multiple modifications in order to alter the expression level of the enzymes might thus be mandatory in order to obtain the desired yield increase.
