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The mechanism for this is not established but evidence supports direct action of KBs together with modifications in levels of hormones, which influence appetite, such as ghrelin and leptin.
Popa et al. [ 23] and Tam et al. [ 24] reported significant modifications in levels of total cholesterol and triglycerides in patients with RA receiving infliximab, but Bosello et al. [ 25] and Peters et al. [ 26] did not find significant changes in lipid levels after treatment with infliximab.
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Varady et al 8 suggest that a minimum weight loss of 5% is required to have an effect on levels of key adipokines (adiponectin, leptin, and resistin), but this differs from other studies which report the need for a 10% weight loss for modification in levels of some adipokines (eg, adiponectin) and that this varies with the degree of obesity.
This independency is further extended to the cell activities inferred from the ontological analysis of transcriptome and translatome differentially expressed genes, with a clear tendency of translation-related genes to be controlled purely at the translational level without modifications in the levels of their transcripts.
The present study was aimed at investigating by a microarray approach whether HdIV injection induces modifications in the levels of S. frugiperda gene transcript levels, resulting either directly from viral gene products or from upstream regulations or feed-back mechanisms.
Modifications in Hb levels before and after hyperventilation, which might have affected Pcv-aCO2 [1], were not reported.
Beyond allelic differences, which can be mapped with QTL-analysis, welfare related biological responses may be mediated by acquired modifications in expression levels of genes and gene complexes.
Modifications in Kit levels were detected both in whole cell extracts and at the cell surface indicating that they in fine may lead to a modified response to SCF.
Using an anti-ser 3 p-cofilin antibody, previously reported to allow for detection of subtle changes in cofilin phosphorylation [34], we could not detect significant modifications in the levels of phosphocofilin after mrTIMP-1 treatment either by western blot (Fig. 3E) or by immunofluorescence (results not shown).
Modifications in the levels of these miRNAs did not affect insulin content or insulin secretion (Fig. 4).
The modifications in the levels of these TCA cycle intermediates coincide with decreased malate dehydrogenase and isocitrate dehydrogenase activities.
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