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Does BAIBA produce similar modifications in humans?
Investigating these modifications in humans could shed light on so far unknown mechanisms of aging.
Histones and their modifications in humans (mammals) are partially addressed in Human Histone Modification Database (HHMD) (40), Histone Database (41) and HIstome (42).
Similarly, additional emerging factors that recognize these modifications in humans can be tested (e.g., Spartan [35,36], ZRANB3 [37 39], and PARI [15]).
In conclusion, the now standardized technologies of epigenome analysis coupled with whole-genome expression studies are required to determine the biological and clinical impact of environmentally induced epigenetic modifications in humans.
In many cases, and for both Trm4 and Trm9, there are two or more human homologues for each yeast tRNA methyltransferases, which suggests diversification or specialization of Trm activity to new modifications in humans, modification of different tRNAs, or functions other than tRNA modification.
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Tamura, I. et al. Genome-wide analysis of histone modifications in human endometrial stromal cells.
Bernstein, B. E. et al. Genomic maps and comparative analysis of histone modifications in human and mouse.
Tatone, C. et al. Age-dependent changes in the expression of superoxide dismutases and catalase are associated with ultrastructural modifications in human granulosa cells.
Modifications in human Cx40 with designed variants (D55N or P193Q, but not P193K) are sufficient to establish morphological and functional heterotypic GJs with Cx45.
We previously proposed the utility of IN mutant lentiviral vectors that are selectively activated by complementary LEDGF/p75 variants, and our initial modifications in human immunodeficiency virus type 1 IN and LEDGF/p75 supported about 13% of wild-type vector transduction activity.
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