Sentence examples for modifications in epigenetic from inspiring English sources
This down-regulation was the result of alterations in the epigenetic programming of the cells, indicating that cooperative inactivation of the RB and p53 pathways can lead to modifications in epigenetic signaling.
There is emerging evidence that modifications in epigenetic processes may be an important causal factor in disease risk throughout the life course.
Modifications in epigenetic regulation of DNA and histones may have a strong amplifying effect since they impact on the transcription of thousands of genes.
Given the importance of histone modifications in epigenetic regulation we further elaborate on the different ways in which histone proteolysis could play a role in epigenetics.
Through subsequent statistical modeling, we were then able to assign histone methylation marks to each positioned nucleosome in CD4+ T cells, revealing the key roles of nucleosome positioning and modifications in epigenetic gene regulation.
Through a transcriptome analysis, we detected a different pattern of mRNA transcription in the liver at birth comparing male vs female and microsomic vs normal mice, noting some modifications in epigenetic regulatory genes in females and modifications in some growth factor genes in males.
A potential CD4+ T-cell lineage intrinsic effect of developmental AhR activation is a modification in epigenetic regulatory machinery.
The major post-translation modifications involved in epigenetic regulation are found in the histone H3 tails, particularly at the lysine 4 (H3K4) and lysine 9 (H3K9) residues.
The identified genomic regions can link to chromosomal aberrations, histone modifications, changes in epigenetic regulation (methylation), regulatory elements and spatial chromosome organization in the nucleus.
DNA methylation and histone acetylation are the main modification patterns in epigenetic reprogramming.
Interestingly, another modification implicated in epigenetic memory, methylation of lysine 4 on histone H3 (H3K4 methylation), is noticeably depleted during Z2/Z3 reprogramming.
