Sentence examples for modifications in embryonic from inspiring English sources

Recent studies showed that susceptible CGI in several cell types are enriched significantly for targets of polycomb group proteins, which are marked with both active and repressive histone modifications in embryonic stem cells (Teschendorff et al., 2010).

- Genome-wide quantification of cytosine modifications in embryonic stem cells (ESCs) estimated 5% of all cytosines to be methylated and approximately 0.5% of them to be hydroxymethylated; the higher oxidized forms, 5-fC and 5-caC, are only present in a few thousand to a few hundred copies per ESC.

Furthermore, many target gene promoters belong to the class of "bivalent promoters" that display a distinct pattern of both activating and repressing histone modifications in embryonic stem (ES) cell lines [ 25], which may allow them to be turned on or off quickly during organogenesis [ 27, 28].

A sub-domain pattern of H4 acetylation is discernable with both H4 antibodies (Figure 3) but appears to be less well defined compared to H3 modifications, as in embryonic cells.

In order to better understand the potential mechanisms of arsenic-induced epigenetic dysfunction, we compared the DMRs found in CAsE-PE cells with known domains of histone modifications in human embryonic stem cells.

To investigate priming of HSPC-specific genes, we investigated their histone modification status in embryonic stem cells (ESCs) using published datasets [ 39].

We show that while homozygosity for the β-cateninE654 targeted modification results in embryonic lethality, heterozygosity for β-catenin E654 is sufficient to initiate intestinal tumour formation and to increase Apc-driven intestinal tumour initiation.

Specifically, global histone modification patterns in embryonic stem cells (ESCs) have revealed the coexistence of trimethylation of histone H3 at lysines 4 and 27 (H3K4me3 and H3K27me3) at promoters of genes encoding key lineage-determining factors (Bernstein et al., 2006).

DNA Methylation is a crucial epigenetic modification involved in embryonic development, transcription, chromation structure, X chromosome inactivation, gene imprinting, chromosome stability and occurrence of different kinds of tumors [ 10- 15].

JARID2 is a component of chromatin modification complex PRC2 in embryonic stem cells and is required for multilineage differentiation.

In recognition of their discovery of how homologous recombination can be used to introduce genetic modifications in mice through embryonic stem cells, Mario Capecchi, Martin Evans and Oliver Smithies were awarded the 2007 Nobel Prize for Physiology or Medicine.