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For instance, CAND1 binding to cullin proteins may be regulated by posttranslational modifications in either of the proteins or by other interacting proteins.
Taken together, it could be possible that the PMA induced loss of interaction between Sp1 and PPARγ might be due to changes in the dynamic post-translational modifications in either Sp1 or PPARγ.
No other patients had dose modifications in either olaparib or bevacizumab.
The TFO can be DNA, RNA or different oligonucleotides with modifications in either their nucleobases or phosphoribose backbone [ 4].
Modifications in either sodium or potassium channel current could also explain the increased tissue refractoriness we observed at high pacing frequencies.
First, we synthesized six siRNA duplexes for the BASP1 target gene with the sequence organization depicted in Figure 5A (see also Supporting Table 1), three of them with a single 2′-azido-2′-deoxycytidine and three of them with a single 2′-azido-2′-deoxyguanosine modification, all of the modifications in either very close vicinity, or directly at the cleavage site.
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The physically adsorbed amphililic PEG serves as a temporary barrier to particle aggregation and allows for convenient solvent exchange for subsequent surface modification in either aqueous or organic solutions.
Nevertheless after six hours post treatment there was an almost complete absence of this FOXO3a modification in either breast or osteosarcoma cancer cells.
Of these, 306 were not associated with the modification in either species, whereas of the 2604 genes that were associated with H3K27me3 in at least one species, 2368 (90.1%) were enriched for H3K27me3 in both species.
Interestingly, using our analytical approach, we did not reproduce the small P-values for effect modification in either of the two previously reported studies, both of which had fewer than 7000 participants.
As expected, in the negative control hbb coding region, no significant change in either modification was observed in response to EGF or DRB.
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