Sentence examples for modifications in disease from inspiring English sources

In order to understand the potential role played by environmental exposures and associated epigenetic modifications in disease processes, it will be critical to understand their functional effects on gene and protein expression, Fry says.

Therefore, this constitutive overabundance of cTfh in RA seems related to disease phenotype and pathogenic mechanisms but not to RA disease activity, as has been reported in patients with SLE [ 16]: Simpson et al. described an expansion of cTfh in a subset of SLE patients with severe disease, which does not vary with time, modifications in disease activity or treatment [ 16].

Mutations or modifications in disease-specific proteins can cause misfolding and consequently formation of aggregates.

Herein, we review recent developments in MS-based quantitative proteomic techniques, HDL proteomics and lipoprotein modifications in diseases, and HDL subfractionation studies.

Thus, this immunoprecipitation assay provides a simple, accessible, reliable and reproducible tool for investigations aimed at documenting the role of post-translational modification in disease.

The findings highlight the importance of overall lifestyle modification in disease prevention, and this information should provide incentive to Asian populations to consider healthy lifestyle choices.

However, recent findings on human gene mutations causing autoimmune diseases are consistent with possible significant roles for RNA modifications in autoimmune diseases.

Because many neurodegenerative diseases are age-related and associated with neuro-inflammation, functional roles of oxidative modifications in these diseases were postulated early on.

(3) The details of host population processes and pathogen transmission dynamics are blended in models that evaluate the effects of natural selection and/or genetic modification in developing disease resistance in the host population.

This study opens new avenues to study the role of specific protein modification in neurodegenerative disease.

There has been a recent increasing awareness of the significance of post-translational protein modifications in health and disease.