Sentence examples for modifications in colon from inspiring English sources

Therefore, we investigated the nuclear expression of three well-studied histone modifications in colon cancer.

In the present study, we used a bottom-up proteomic approach to investigate alterations in histone modifications in colon cancer samples and their normal counterparts.

DACT1 was frequently downregulated by promoter methylation in HCC, whereas another DACT family member, DACT3, was repressed by bivalent histone modifications in colon cancer [ 16, 27].

Despite the evident role of histone modifications in colon cancer, histone modification profiles have not been analyzed in coupled normal and tumor colon samples.

Second, we selected 10 of 21 genes (ABCA8, AQP8, HPGD, PRDX6, SLC26A3, STX12, NDRG2, MXI1, SGK2, and SCNNB1) as possible targets of epigenetic modifications in colon cancer, and after treatment with a demethylating agent, seven of them showed a significant increase of mRNA expression (AQP8, HPGD, PRDX6, MXI1, SCNNB1, SGK2 and NDRG2).

Aberrant DNA methylation at the 5-carbon on cytosine residues (5mC) in CpG dinucleotides is probably the most extensively characterized epigenetic modification in colon cancer.

Numerous proteins appeared in multiple bands, at different molecular weights (e.g., DMBT1, carbonic anhydrase 1, neutrophilic elastase), suggesting a possible degradation and/or various post-translational modifications in the colon lumen.

Gene and protein expression, DNA methylation, and histone modifications were measured in colon and liver of female offspring.

Thus we provide evidence for the existence of either chromosomal instability or epigenetic modification of ACVR2 in colon cancer and identify a cell model for epigenetic silencing of ACVR2.

Because global histone acetylation changes preceded alterations in other histone modifications, we conducted ChIP assays in colon cancer cells at an early time point, 4 h.

Since the amount of intestinal tissue of 2-week-old mouse pups is very limited and all available material was used for RNA and DNA isolation, we were not able to examine histone modifications in the SI and colon tissue in more detail.