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Some other features of a flow system and the modifications in cell design and operation due to the stirring are briefly discussed.
Protein kinase C (PKC) and calcium/calmodulin-dependent protein kinase II (CaM KII) are two pivotal signaling agents that mediate several of these rapid modifications in cell structure.
Taken these evidences together it may envisage that modifications in cell metabolism precede and possibly dictate the nature of the ultimate cellular differentiation.
Modifications in cell motility can probably be linked to targeting of genes such as RHEB and CYR61, two important regulators of cell adhesion, which were validated by luciferase assays (Figure S1A).
These results indicate dramatic modifications in cell shape and organization that neutrophils are capable of performing.
Ultrastructure of 'slimmed' adipocytes revealed severe delipidation and modifications in cell membrane conformation.
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H3K14ac (acetylation of lysine 14 of histone H3) is one of the most important epigenetic modifications in cells.
To investigate transcript-wide regulation of mitochondrial tRNA stoichiometry and RNA modifications in cells harboring the MERRF mutation, we used demethylase-thermostable group II intron RT tRNA sequencing (DM-tRNA-seq 17.
From these data, and that from previous work which demonstrates little to no cell death in 2CLP monolayers following 2 days in culture, allow us to conclude that reduced TER in 2CLP monolayers are due to paracellular pathways of ion motion, possibly due to modifications in cell-cell junctions, not increased cell death [23].
We next examined the bulk histone modifications in cells treated with DZNep, TSA or both.
In the cell system, there is a major contribution of post-translational modifications in cells to the expressed protein for efficient secretion and stability.
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