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These modifications differ along time evolution of sepsis corresponding to modifications in blood constitution being responsible for waves of up- or down-regulation of inflammation [201].
Our group has observed that unilateral lesions of the nigrostriatal pathway in rat brain produce simultaneous modifications in blood pressure and aminopeptidase activities, both in brain and plasma, curiously depending on the side of the lesion.
Active smoking is an established critical factor for epigenetic modifications in blood DNA [ 4].
Our study was based on measures of histone modifications in blood leukocyte samples from healthy subjects, thus suggesting that exposure-related alterations of histone modifications may occur in normal tissues and possibly anticipate the onset of disease.
Our findings might be extended to ambient air pollution exposures, as suggested by our related investigations demonstrating repetitive element hypomethylation, as well as other gene-specific modifications, in blood DNA from individuals exposed to airborne benzene (Bollati et al. 2007) or to ambient particulate matter (Baccarelli et al. 2009).
In this systematic review, we identified 17 studies addressing the association of active smoking exposure with methylation modifications in blood DNA, including 14 recent epigenome-wide association studies (EWASs) and 3 gene-specific methylation studies (GSMSs) on the gene regions identified by EWASs.
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Introduction: Acute respiratory failure (ARF) can be divided in hypoxemic or hypercapnic, depending on the leading modification in blood gas analysis, being the first one the most common.
The present study, based on a healthy worker population from a steel plant near Brescia, Italy, showed that exposure to some metal components of PM was associated with increased activating histone modifications measured in blood leukocyte samples.
Interestingly, when ketanserin was bilaterally injected into RVLM, a significant enhancement of BRS was found and there were no modifications in basal blood pressure and heart period.
During acute exercise, modifications in mononucleated blood cells occur [ 7].
Regional modifications in cerebral blood flow have been studied during hand motor tasks [ 104].
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