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Protein phosphorylation is one of the most prominent, and intensively studied post-translational modifications in biological systems.
Proteomics can be defined as the high-throughput study of global patterns of protein expression and post-translational modifications in biological systems.
Near-shore marine coastal environments are experiencing considerable changes in temperature and oxygen availability due to anthropomorphic influences, which has triggered considerable modifications in biological communities [ 1].
Graphical representation of upregulated and downregulated genes was performed in R. Chromatin immunoprecipitation of histone modifications were performed according to Lee et al. (2006) with minor modifications, in biological duplicate for H3K27ac, Suz12 and FLAG.
So far, the levels of specific histone modifications, such as H3K18Ac, H4K12Ac, H3K4Me2, and H4R3Me2, have been shown to correlate with prostate cancer tumor stage [ 110]; but without a reliable method to detect these modifications in biological fluids, progress has been slow.
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For instance, one substance when used alone presents modification in biological responses, i.e. it increases cytokine production by cells, but when combined to another substance the effects on biological responses are annulled (data not published yet).
Although O-glycosylation is a typical posttranslational modification in biological systems, occurring in the Golgi apparatus, synthetic versions of this procedure, in which sugar chains are attached after the expression of core proteins, can only be performed in a limited manner.
Recent studies have implicated H3K9 modifications in numerous biological phenomena including germ cell development, X chromosome inactivation, DNA damage repair and apoptosis [14].
This finding highlights the importance of studying the role of posttranslational modifications in relevant biological contexts.
In summary, the kinetics of placental and foetal growth altered by ART may be linked to modifications in various biological pathways, probably triggering the placental compensation phenomenon.
Despite the crucial roles of histone modifications in various biological processes, there has been no systematic investigation to date of the extent of human ASHM genome-wide.
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