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59 The identification of lipodystrophy has had significant implications on the management of HIV, and its recognition as a side effect of ART has led to reevaluation of the appropriate time to start ART, delay initiation of ART, and also to different modifications in ART for HIV treatment.
In addition, to date, no study has focused on histone modifications in ART placentas, although higher concentrations of H3K4 trimethylation have been found in mouse blastocysts cultured in vivo than in vitro [ 183].
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Modifications in first ART regimen were due to side effects, drug toxicity, or switch to newly available drugs.
"Obviously we've seen a modification in the art market," he added.
The following sections organize ART modifications in patients with stably suppressed virus according to the ARV class of a drug that requires discontinuation and the ARV class of its replacement drug.
A confirmation came from Khosla et al. showed that preimplantation mouse embryos cultured in the presence of serum can change the expression and methylation of several imprinted genes (such as H19, IGF2, GRB10, and GRB7) and that these aberrant epigenetic modifications lead to abnormal fetal growth in ART animals [ 120].
As mentioned above, these phenotype modifications of the foetus and placenta are found in ART pregnancies.
"Art in, art out".
Herein, often, lies the art in art.
"Even in art, yes.
It happens in art.
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