Sentence examples for modifications implicated in from inspiring English sources
The identification of all epigenetic modifications implicated in gene expression is the next step for a better understanding of human biology in both normal and pathological states.
For example, some authors recently suggested that endometriosis may be accompanied by epigenetic modifications implicated in diminished endometrial receptivity and altered gene expression.
The abnormal expression of HERV-K seemingly triggers pathological processes leading to melanoma onset, but also contributes to the morphological and functional cellular modifications implicated in melanoma maintenance and progression.
We assessed genome-wide mRNA, microRNA, and three common histone modifications implicated in gene activation for young and aged virgin and mated female D. melanogaster in a factorial design.
The abnormal expression of HERV-K seemingly triggers the pathological processes leading to melanoma onset, but also contributes to the morphological and functional cellular modifications implicated in melanoma maintenance and progression [ 62]. Figure 1 shows the presumed cascade of events between HERV-K expression and melanoma initiation.
Ubiquitination is not the only covalent modification implicated in proteolysis and neurodegeneration.
An additional post-translational modification implicated in neurodegeneration is phosphorylation, which can vary between soluble and aggregated states.
SUMO (Small Ubiquitin-like MOdifier) conjugation is a post-translational modification implicated in a variety of cellular functions including transcriptional regulation, nuclear location and signal transduction.
Interestingly, another modification implicated in epigenetic memory, methylation of lysine 4 on histone H3 (H3K4 methylation), is noticeably depleted during Z2/Z3 reprogramming.
An Arf/Arl/Sar co-conserved tryptophan within the C-terminal end of the GTPase domain Trp172-Arf11 in Fig. S2C of Additional File 1) is located structurally near the N-terminal myristate moiety [ 22]--a posttranslational modification implicated in membrane association and a feature required for the biological function of Arf GTPases.
Epigenetic gene regulation, such as DNA methylation and histone modifications, is implicated in lineage specification and maintenance.
