Exact(1)
We acknowledge, however, that including either mutant IDH or H3.3 proteins in our mNPC system could promote additional epigenomic modifications, impacting transcriptional and phenotypic profiles.
Similar(59)
To begin to investigate how modifications impact allostery in KMD5A, we performed competition-based FP assays to determine affinities of a panel of modified peptides (Fig. 4a).
There is limited information on how these modifications impact the evolved mechanisms of photosynthetic energy metabolism and cellular growth.
It turns out that with the current state of the art, the modifications impact non-technical system attributes.
Yet, it is not known whether the mechanisms that bring about such modifications impact the quantitative or kinetic properties of gene expression.
In recent years, despite the underlying mechanisms of cardiac fibrosis are still unknown, numerous studies suggest that epigenetic modifications impact on the development of cardiac fibrosis.
Particularly, loop-1 modifications impact on the dynamics of a distant region that includes residues from the β-sheet, helix α1 and the C-terminal.
"A lot of the model systems we have studied suggest that epigenetic modifications impact behavior, and also that those effects can be reversed," said Thomas Lehner, chief of the genomics research branch of the National Institute of Mental Health.
With a view to understanding how structural/chemical modifications impact the solar cell performances, recent efforts have focused on creating quantitative structure property relationships [26, 29 36] that establish a mathematical relationship between various molecular structure descriptors and a solar cell property of interest such as the PCE.
Our understanding of the molecular and structural mechanisms of how these modifications impact transcriptional activity remains inadequate.
Histone modifications impact on chromatin architecture and gene expression 15.
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