Sentence examples for modifications have important from inspiring English sources
In addition to smoking, chromosomal translocation and epigenetic modifications have important roles in the development of lung cancer [91 94].
Thus, it appears that the cRGD and PEG modifications have important and additive contributions.
DNA methylation and histone modifications have important roles in normal mammary differentiation and the development of breast cancer.
It has become clear that both genetic predisposition and environmental factors play critical roles in the development of metabolic diseases including obesity and type 2 diabetes, and epigenetic modifications have important roles in altering gene expressions in various chronic diseases [ 46– 46].
Reviewer 2: Sandor Pongor - International Centre for Genetic Engineering and Biotechnology, Trieste, Italy There is mounting evidence in recent years that the study of post-translational modifications has important lessons for understanding diverse aspects of protein evolution.
Although effect modification has important public health implications [ 74], this issue has so far received limited attention, probably because of methodological complexity and the difficulty in data interpretation.
This process of dual lipid modification has important implications in intracellular trafficking, secretion and range of action of the Hh ligand.
Collectively, recent findings have demonstrated that the ubiquitin-proteasome system as a common posttranslational modification has important roles in the maintenance of pluripotency in mouse and human ESCs [ 78, 79] as well as pluripotent reprogramming [ 78].
It is anticipated that histone modifications would have important functions in regulating centromere biology, as histones are extensively modified post-translationally and covalent histone modifications have an essential contribution to the regulation of chromatin functions, they correlate with different functional states and are involved in chromatin assembly/disassembly processes.
These modifications might have important effects on sound transmission of the middle ear [34].
Such modifications should have important implications for signaling identity and quality in sexual selection.
