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Hydrophobic modifications have emerged as a promising approach to improve the efficiency of non-viral gene delivery vectors (GDV).
Chromatin modifications have emerged as a basic core mechanism in transcriptional regulation.
Recently, oxidative cysteine modifications have emerged as a central mechanism for dynamic post-translational regulation of almost all major protein classes, and correlate with many disease states.
In addition to acetylation, novel mitochondrial post-translational modifications have emerged that may reflect the metabolic state, including succinylation and malonylation (Du et al, 2011; Peng et al, 2011).
Recently, modifications in the chromatin structure by the loss or gain of DNA methylation and post-translational histone modifications have emerged as important contributors in tumor formation [ 3]‐[ 5].
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In the past decade, new technologies for genetic modification have emerged and known as genome-editing technologies.
In recent years, the epigenetic mechanisms that control chromatin structure and function, including DNA methylation and histone modification, have emerged as key factors in the regulation of cell growth and differentiation and, thereby, the nuclear reprogramming necessary for dedifferentiation [4].
Recently, epigenetic aberrations, including DNA hypermethylation and/or histone modification, have emerged as a major cause in miRNA deregulation [ 80– 82].
In addition, epigenetic regulations, such as DNA methylation and histone modification, have emerged as a key driver of cell fate and their disruption could be related to a variety of human diseases [ 13– 17].
This century, the descendant of genetic modification has emerged as synthetic biology.
Reactive oxygen species-mediated cysteine sulfenic acid modification has emerged as an important regulatory mechanism in cell signaling.
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