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Many enzymes responsible for these modifications have been identified and they require various metabolic cofactors or substrates for their activity.
To date, well over a hundred nucleotide modifications have been identified in diverse types of RNA molecules (3).
Several mitochondrial rRNA methyltransferase and mitochondrial tRNA modifications have been identified in human, but the proteins involved in these modifications are far from being all identified.
The most significant microstructural modifications have been identified in the outlet part of the tube where especially harsh operating conditions, in terms of temperature, fuel utilization and polarization gradients, occur.
A number of histone tail modifications have been identified including acetylation, phosphorylation, ubiquitination, and methylation [1].
Three types of formaldehyde-induced chemical modifications have been identified in proteins and model peptides: (a) methylol (hydroxymethyl) adducts, (b) Schiff's bases, and (c) stable methylene bridges [9], [10].
Similar(38)
Among the technologies to control SO2 emission from coal-fired boilers, the dry flue gas desulphurization (FGD) method, with appropriate modifications, has been identified as a candidate for realizing high SO2 removal efficiency to meet both technical and economic requirements, and for making the best quality byproduct gypsum as a useful additive for improving alkali soil.
Initial analysis of this mapping reveals changes in nucleosome positioning in promoters where gene expression and histone modifications had been identified to be significantly altered in cells expressing high and low levels of MMSET.
SUMO modification usually is reversible, and multiple SUMO-specific proteases that remove the modification have been identified [5], [6].
Recently, epigenetic mechanisms, such as DNA methylation and histone modification, have been identified as contributors to the disease phenotype [8].
Importantly, recurrent mutations in several genes affecting histone modification have been identified [ 48].
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