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Structural modifications guided by structure activity studies have resulted in the identification of potent compounds.
Further genetic modifications guided by metabolic modeling and feedback inhibition mitigation were introduced to increase precursor availability.
No benefit found on the clinical improvement following the modifications guided by monitoring (50 vs 57%, p = 0.72) and (31 vs 47%, p = 0.074) for the hemodynamic and respiratory responses respectively.
Aminoglycoside dosing is based on weight and kidney function, with subsequent dosage modifications guided by therapeutic drug monitoring.
Prediction of the modifications guided by these RNAs and using partial mapping data, 84 2'- O-methyls (Nms) and 32 pseudouridines were identified on rRNAs, suggesting a high occurrence of Nms as compared to pseudouridines on rRNA.
Similar(55)
An extensive analysis of snoRNA genes from Neurospora crassa indicated a high diversity of post-transcriptional modification guided by snoRNAs in the fungus kingdom [ 22].
Duplexes between tRNA and snoRNAs have been also found in C. elegans [ 24] and recently in Plasmodium falciparum [ 47]. tRNA modification guided by snoRNAs has been also reported in Archaea [ 23].
As compared with two yeasts, a more complex pattern of methylation guided by box C/D snoRNAs in multicellular fungus than in unicellular yeasts was revealed, indicating the high diversity of post-transcriptional modification guided by snoRNAs in the fungus kingdom.
These terrain modifications were guided by Figures 2 and 3, satellite photographs from Google Earth [23] and NASA World Wind [24], and geological surveys of the northeastern Nile delta [13], [6].
Chemotherapy modification was permitted at the discretion of the primary treating physician when patients experienced grade 3 toxicity and the modification was guided by the designs of the original trials.
Many structural modifications of peptides guided by rational design and molecular modeling have been established to develop novel synthetic approaches.
Related(16)
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