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Thus, the model needs modifications for our case since we are using a different catalyst.
The obtained theoretical studies are in agreement with the in vitro bioassay screening results, which supports the importance of the structural modifications for our studied compounds.
In addition, although we already considered some peptide modifications for our database searches, such as carbamidation of cysteines or oxidation of methionines, other types of modifications can occur and impair database searches and protein identifications.
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Table 1 shows a comparison of the reaction conditions between the original method and the modification for our HT assay.
Although the methods were designed for a different type of biomedical relation, they did not require any modification for our application.
While potentially applicable to all sequencing platforms, we developed SuBLiME technology using SOLiD sequencing, as linker sequences were readily amenable to necessary modification for our protocol (Table S1 ).
For some modifications of our proposed algorithm, the suggested median filter post-processing reduced the average error by 34%.
There is no need for special modification of our method for actual robots, and we have already applied it to simple pushing tasks by an industrial manipulator successfully [20,22].
To enable further development of Rocker, it is freely available (MIT-GPL license) for use and modifications from our web-site (http://www.jyu.fi/rocker).jyu.fi/rocker
The modifications of our inference algorithm for use of η different paths are illustrated next: Step 1: η different paths from BN1 are selected and set as synthetic data (SD1, SD2... SD η).
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