Since neurexins are known to be glycosylated we examined peptides for the presence of consensus sequences for carbohydrate modifications and excluded peptides with potential post-translational modification from our assays.
To measure the sub-species of transthyretin that were identified by 2D-DIGE as decreasing in AD will require assays that specifically target relevant post-translational modifications and exclude other forms of transthyretin.
Subjects with diseases potentially linked to diet and dietary modifications were excluded from the control group, and major confounding factors of prostate cancer were adjusted for.
Any patients meeting any exclusion criteria, those on vasoactive drugs, such as prostanoids, or patients undergoing frequent treatment modifications, were excluded.
Genome-wide histone modification maps from C. elegans and human revealed that intron-exon chromatin is also preferentially marked, with transcriptionally active modifications generally excluded from introns and concentrated in exons [ 5- 11].
Peptide fragments in the 0.05% hydrogen peroxide monomer containing no modifications were excluded from analysis because they contain no information about the percent exposure of residues in the fibril.
However, possible sources of selection bias are limited in our study, as cases and controls were drawn from the same catchment areas, participation was almost complete, and women with diseases potentially related to diet and dietary modifications were excluded from the control group.
Therefore only restricted modifications are possible (excluding glycosylation).
For the effect of PM10 on cough (Table 4), there were higher associations in studies conducted outside of Europe, with lag > 2 days, or with higher NO2 levels; these effect modifications remained when excluding the PEACE studies.
Modifications such as excluding low-fat dairy products or white meats from the detrimental foods, or incorporating additional unhealthy food groups (e.g., soft drinks, salty snacks, pastries) as detrimental components, had no meaningful impact on findings in sensitivity analyses (data not shown).
This modification helped exclude data from voxels that were too noisy or did not contain useful information, thus improving the signal-to-noise ratio in the output.
