The modifications do not dramatically increase the computational cost of simulation.
These substitutions and modifications do not affect the ability of probes to bind Zn2+.
Preliminary results indicated that these modifications do not seriously alter the molecular recognition properties of APNAs towards DNA and RNA.
"DNA Modifications Do Not Impede Cas9 Activity" at 114th General Meeting of the American Society for Microbiology, Boston, Massachusetts.
Our proposed modifications do not degrade the simulated results, while they lead to more robust convergence performances and cost-effective simulations.
But the modifications do not go nearly far enough to persuade the Real Estate Board of New York to drop its blanket opposition.
A small study indicates that these modifications do not significantly impact the quality of designs, while reductions in effort of over 90% can be achieved.
More importantly, these modifications do not alter the level of transgene expression in non-NA cells either in vitro or in vivo, demonstrating tight cell-type specificity.
Lastly, we observe that most actions needed to reach unsatisfied criteria may be solved in the design stage, and these modifications do not require large investments.
These modifications do not, however, refute the generalization that Calvinism was largely opposed to art and music in the service of religion but not in the secular sphere.
Such modifications do not have to weaken the bill substantially, he added".Sometimes clarification can have the appearance of change," he said.
