Nucleosomal packaging and histone modifications dictate the different degrees of primary chromatin compaction [ 14] achieved by additional chromatin structural proteins.
H3 modifications dictate demethylation activity enhancement in KDM5A.
Nucleosomal packaging and histone modifications dictate the different degrees of primary chromatin compaction, e.g., six nucleosomes per 11 nm in the euchromatic chromatin fiber vs. 12 15 nucleosomes per 11 nm in heterochromatin, which is achieved by additional chromatin structural proteins.
The bipedal gait of birds, dictated by modification of the forelimbs for flight, necessitates manipulation of food by the bill and feet.
Recently, we speculated that substrate specificity of proteases could be dictated by posttranslational modifications, an issue that has not been investigated in detail before (Kasperkiewicz et al. 2012).
Many cellular events are dictated by covalent modification of proteins, an important mechanism in regulating protein and genome function; of which protein methylation is an important posttranslational modification with activating or repressive effects.
Splicing efficiency, as well as alternative splicing patterns, could thereby be dictated by the availability, modifications, or expression levels of these proteins.
Other cell type-specific differences may be dictated by post-translational modifications of NF90; although NF90 is phosphorylated by kinases such as PKR, PKC, and AKT [ 39- 42], such modifications have been proposed to affect its RNA-binding function, but they are not fully understood at present.
The susceptibility of cysteine residues to modification by a defined RLS is dictated by a combination of factors including the p Ka of the thiol and the local pH of the intracellular compartment.
The exquisite control of growth factor function by heparan sulfate (HS) is dictated by tremendous structural heterogeneity of sulfated modifications.
