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Following reactor and process modifications, close to 80% capture was achieved.
Interestingly, deletion of snR36 or snR85, two H/ACA snoRNAs that direct modifications close to Rps15p's binding site on the rRNA, produces mild and opposite effects on growth in an rps15 hypomorphic background.
Individual reader domains are sensitive to the presence of histone modifications close to their main target residue, and most chromatin associated proteins contain several histone binding domains.
We propose that this bipartite binding mechanism is a distinctive and general property in the recognition of histone modifications close to the nucleosome core.
We propose that this mechanism also applies to the recognition of other modifications close to the nucleosome core, such as H4K20me and H3K79me.
Moreover, the bipartite binding mode observed for PSIP1 may extend beyond PWWP domains to other domains that bind H3K36me as well as to the recognition of other histone modifications close to the nucleosomal DNA, such as H4K20me.
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To study the modes (or groups) of histone modifications that are employed by the TCM medicinals, we place the modifications closer in Figure 3 if they are more similarly utilized by the medicinals (see the hierarchical clustering in Methods).
The five technical components (Figure 2) of an ECP are: 1) input data (entered manually or captured electronically from devices); 2) a control unit that analyses the input data to generate orders; 3) output data; 4) an interface that display a recommendation (open-loop) or implements the setting modification (closed-loop); and 5) a virtual patient as mentioned above.
The five technical components of an ECP are: 1) input data (entered manually or captured electronically from devices); 2) a control unit that analyses the input data to generate orders; 3) output data; 4) an interface that display a recommendation (open-loop) or implements the setting modification (closed-loop); and 5) a virtual patient as mentioned above.
We show that a few modifications largely close this gap and we give a few examples of feasible spectrum-covering designs.
The recruitment mechanism with RE = 0.5 (so a low initiation rate) yields a modification pattern close to the initiation sites.
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